Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
We found that PHF19 transcript and protein levels were significantly elevated in human glioma tumors, which was negatively associated with expression of the anti-PHF19 microRNA miR-124a. miR-124a over-expression in the A172 and U251MG glioma cell lines and patient glioma cells suppressed PHF19 expression, EZH2 activation, and cell proliferation.
|
30131250 |
2018 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Abnormal expression of PHF19 causes dysplasia or serious diseases, including chronic myeloid disorders and tumors.
|
30323224 |
2018 |
Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We found that PHF19 transcript and protein levels were significantly elevated in human glioma tumors, which was negatively associated with expression of the anti-PHF19 microRNA miR-124a. miR-124a over-expression in the A172 and U251MG glioma cell lines and patient glioma cells suppressed PHF19 expression, EZH2 activation, and cell proliferation.
|
30131250 |
2018 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrated that PHF19 expression was positively associated with GBM progression, including cell proliferation, migration, invasion, chemosensitivity, and tumorigenesis.
|
30323224 |
2018 |
Ewings sarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PHF19 expression was also associated with worse prognosis in patients with EWS.
|
29898995 |
2018 |
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we demonstrated that PHF19 expression was positively associated with GBM progression, including cell proliferation, migration, invasion, chemosensitivity, and tumorigenesis.
|
30323224 |
2018 |
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Restoration of PHF19 expression markedly reversed the inhibitory effect of miR-211 on OC.
|
29874124 |
2018 |
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Restoration of PHF19 expression markedly reversed the inhibitory effect of miR-211 on OC.
|
29874124 |
2018 |
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In this latter group the expression of either Phf19 or Sdc2 was shown to increase HC11 cells invasion capability.
|
23131872 |
2012 |
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrated that PHF19 expression was positively associated with GBM progression, including cell proliferation, migration, invasion, chemosensitivity, and tumorigenesis.
|
30323224 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Restoration of PHF19 expression markedly reversed the inhibitory effect of miR-211 on OC.
|
29874124 |
2018 |
Rheumatoid Arthritis
|
0.120 |
Biomarker
|
disease |
BEFREE |
Our results underscore an unrecognized but critical function for Phf19 in GCs formation and antibody generation, and implicate the potential role of Phf19 in RA pathogenesis.
|
29423005 |
2018 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Using various MM models, we demonstrated a critical requirement of PHF19 for tumor growth in vitro and in vivo.
|
31383640 |
2019 |
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Survival analysis then revealed a five-PcG gene signature one protective gene (enhancer of zeste homolog 1) and four risky genes (EZH2, PHD finger protein 19, DNMT3A and DNMT3B), which may identify patients with high risk of poor prognosis of glioma.
|
28454437 |
2017 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings establish the miR-155-Phf19-PRC2 as a pivotal axis regulating CD8<sup>+</sup> T cell differentiation, thereby paving new ways for potentiating cancer immunotherapy through epigenetic reprogramming of CD8<sup>+</sup> T cell fate.
|
31089138 |
2019 |
Leukemia, Plasma Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overexpression and/or genomic amplification of PHF19 is found associated with malignant progression of MM and plasma cell leukemia, correlating to worse treatment outcomes.
|
31383640 |
2019 |
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this report, we show that PHF19 silencing reduces the cell proliferation rate and increases the transendothelial migration capacities of melanoma cell lines.
|
22487681 |
2012 |
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RNA-sequencing-based transcriptome profiling in MM lines also demonstrated a requirement of PHF19 for optimal silencing of PRC2 targets, which include cell cycle inhibitors and interferon-JAK-STAT signaling genes critically involved in tumor suppression.
|
31383640 |
2019 |
Ovarian Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma.
|
29874124 |
2018 |
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis.
|
30323224 |
2018 |
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis.
|
30323224 |
2018 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings establish the miR-155-Phf19-PRC2 as a pivotal axis regulating CD8<sup>+</sup> T cell differentiation, thereby paving new ways for potentiating cancer immunotherapy through epigenetic reprogramming of CD8<sup>+</sup> T cell fate.
|
31089138 |
2019 |
Rheumatoid Arthritis
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.
|
24782177 |
2014 |
Rheumatoid Arthritis
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.
|
24782177 |
2014 |
Rheumatoid Arthritis
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |